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Innovations and Challenges in Prostate Cancer: Defining and Treating "High Risk" Disease

Fifth Cambridge Conference
November 2005

Table of Contents

Recommendations for Defining and Treating High Risk Localized Prostate Cancer
IM Thompson, PR Carroll, MA Carducci

Identifying Men Diagnosed with Clinically Localized Prostate Cancer Who Are at High Risk for Death from Prostate Cancer
AV D'Amico, M Hui-Chen, AA Renshaw, B Sussman, KA. Roehl, WJ Catalona

Defining High Risk Prostate Cancer with Risk Groups and Nomograpms: Implications for Designing Clinical Trials
M Roach III, V Weinberg, M Nash,  HM Sandler, PW McLaughlin, and MW Kattan

Defining High Risk Prostate Cancer - Where Do We Set the Bar?

A Translational Science Approach to Risk Stratification.
IM Thompson

Initial therapy with radical prostatectomy for high risk, localized prostate cancer
JE Montie

The Case for Adjuvant Therapy of Prostate Cancer
LM Glodé

Management of Locally Advanced Prostate Cancer: Past, Present, Future
GP Swanson

The Case for Systemic Therapy Alone
C Sweeney

Case for androgen deprivation as primary therapy in early stage disease: results from J-CaP and CaPSURE
H Akaza, S Hinotsu, M Usami, O Ogawa, S Kagawa, T Kitamura, T Tsukamoto, S Naito, Y Hirao, M Murai, H Yamanaka, M Namiki

Bone-related Events in High Risk Prostate Cancer
S Srinivas and N Colocci

Management of High Risk Metastatic Prostate Cancer: Defining Risk at the Time of Initial Treatment Failure
SS Chang

High-Risk Biochemical Relapse and the Timing of Androgen Deprivation Therapy
EJ Small and CJ Ryan

The Case for Early Chemotherapy for the Treatment of Metastatic Disease
A Lucas and DP Petrylak

The Case for Secondary Hormonal Therapies in the Chemotherapy Age
EJ Small and CJ Ryan

Management of High Risk Metastatic Prostate Cancer: The Case for Novel Therapies
TC Brand and A Tolcher