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Innovations and Challenges in Melanoma

First Cambridge Conference
July 2005

Table of Contents

Innovations and challenges in melanoma: consensus statement from the first international conference
MB Atkins, DE Elder, R Essner, KT Flaherty, TF Gajewski, FG Haluska, P Hwu, U Keilholz, JM Kirkwood, JW Mier, MI Ross, CL Slingluff, VK Sondak, JA Sosman, MA Weinstock, and L King

Progress and prospects on melanoma: the way forward for early detection and reduced mortality
MA Weinstock

Genetic alterations in signaling pathways in melanoma
FG Haluska, H Tsao, H Wu, FS Haluska, A Lazar, and V Goel

Pathology of melanoma
DE Elder

Early stage melanoma: staging criteria and prognostic modeling
MI Ross

Sentinel lymph node biopsy and melanoma biology
R Essner

Identifying and overcoming immune resistance mechanisms in the melanoma tumor microenvironment
TF Gajewski

Strategies for the development of more effective adjuvant therapy of melanoma: current and future explorations of antibodies, cytokines, vaccines, and combinations
JM Kirkwood, S Moschos, and W Wang

Melanoma vaccines: where have we been and where are we going?
VK Sondak, MS Sabel, and JJ Mulé

Peptide and DC vaccines
CL Slingluff, Jr, VH Engelhard, and S Ferrone

Immune monitoring of T-cell responses in cancer vaccine development
U Keilholz and C Scheibenbogen

Cytokine-based and biochemotherapy for advanced melanoma
MB Atkins

Improving antitumor responses by circumventing immune regulatory mechanisms
G Lizée, LG Radvanyi,  WW Overwijk, and P Hwu

Chemotherapy and targeted therapy combinations in advanced melanoma KT Flaherty

Targeting the MAP kinase pathway in the treatment of malignant melanoma
DJ Panka, MB Atkins, and JW Mier

Molecular targets in melanoma from angiogenesis to apoptosis
JA Sosman and I Puzanov