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Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer

Second Cambridge Conference
June 2002

Table of Contents

Second International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: Summary Consensus Statement
Steven E. Come, Aman U. Buzdar, Carlos L. Arteaga, Angela M. Brodie, Nancy E. Davidson, Mitch Dowsett, James N. Ingle, Stephen RD Johnston, Adrian V. Lee, C. Kent Osborne, Kathleen I. Pritchard, Victor G. Vogel, Eric P. Winer, Carol Hart

Breast Cancer Endocrine Resistance – How Growth Factor Signaling and Estrogen Receptor Coregulators Modulate Response
Rachel Schiff, Sulieman Massarweh, Jiang Shou, and C. Kent Osborne

Predictions from a Preclinical Model:  Studies of Aromatase Inhibitors and Antiestrogens
Angela Brodie, Danijela Jelovac, and Brian J. Long

Endocrine Therapy of Advanced Disease: Analysis and Implications of the Existing Data
Kathleen I. Pritchard

Pharmacology and Pharmacokinetics of the Newer Generation Aromatase Inhibitors
Aman U. Buzdar

Clinical Differences Among the Aromatase Inhibitors
Jennifer A. Ligibel, Eric P. Winer

Adjuvant Endocrine Therapy in Postmenopausal Breast Cancer
James N. Ingle

Adjuvant Hormonal Therapy for Premenopausal Women with Breast Cancer
Leisha A. Emens and Nancy E. Davidson

NSABP Update: Prevention Trials and Endocrine Therapy of DCIS
Victor G. Vogel, Joseph P. Costantino, D. Lawrence Wickerham, and Walter M. Cronin

Preoperative Models to Evaluate Endocrine Strategies for Breast Cancer
Mitch Dowsett

ErbB (HER) Receptors Can Abrogate Antiestrogen Action in Human Breast Cancer by Multiple Signaling Mechanisms
Hirokazu Kurokawa and Carlos L. Arteaga

New Mechanisms of Signal Transduction Inhibitor Action:  Receptor Tyrosine Kinase Downregulation and Blockade of Signal Transactivation
Adrian V. Lee, Rachel Schiff, Xiaojiang Cui, Deepali Sachdev, Douglas Yee, Andrew Gilmore, Charles Streuli, Steffi Oesterreich, and Darryl Hadsell

Integration of Signal Transduction Inhibitors with Endocrine Therapy--An Approach to Overcoming Hormone Resistance in Breast Cancer
Stephen RD Johnston, Julia Head, Sunil Pancholi, Simone Detre, Ian E Smith and Mitch Dowsett