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Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer

Fourth Cambridge Conference
June 2004

Table of Contents

Proceedings of the Fourth International Conference on Recent Advances and Future Directions in Endocrine Therapy for Breast Cancer:  Conference Summary Statement
Steven E. Come, Aman U. Buzdar, James N. Ingle, Carlos L. Arteaga, Angela M. Brodie Graham A. Colditz, Stephen RD Johnston, Vessela N. Kristensen, Per E. Lønning, Donald P. McDonnell, C. Kent Osborne, Jose Russo, Richard J. Santen, Douglas Yee, and Carol Hart

Crosstalk Between ER and Growth Factor Receptor Pathways as a Cause for Endocrine Therapy Resistance in Breast Cancer
C. Kent Osborne, Jiang Shou, Suleiman Massarweh, Rachel Schiff

The Molecular Pharmacology of Estrogen Receptor Modulators: Implications for the Treatment of Breast Cancer
Donald P. McDonnell

Gene Expression Profiling of Breast Cancer in Relation to ER Status and Estrogen-Metabolizing Enzymes: Clinical Implications
Vessela N. Kristensen, Therese Sørlie, Jurgen Geisler, Anita Langerød, Noriko Yoshimura, Rolf Kåresen, Nobuhiro Harada, P. E. Lønning, Anne-Lise Børresen-Dale

Therapeutic Observations in MCF-7 Aromatase Xenografts
Angela Brodie, Danijela Jelovac, Luciana Macedo, Gauri Sabnis, Syreeta Tilghman, and Olga Goloubeva

Combinations of Endocrine and Biologic Agents: Present Status of Therapeutic and Presurgical Investigations
Stephen RD Johnston

Endocrine Therapy Trials of Aromatase Inhibitors for Breast Cancer in the Adjuvant and Prevention Settings
James N. Ingle

TAS-108 - A Novel Steroidal Antiestrogen
Aman U. Buzdar

Estrogen, Estrogen Plus Progestin Therapy, and Risk of Breast Cancer
Graham A. Colditz

Exemestane for Breast Cancer Prevention - A Feasible Strategy?
Per E. Lønning

Tamoxifen versus Aromatase Inhibitors for Breast Cancer Prevention
W. Yue, J-P Wang, Y. Li, W. Bocchinfuso,, K. Korach, P. Devanesan, E. Rogan, E. Cavalieri and R.J. Santen

Breast Differentiation and Its Implication in Cancer Prevention
Jose Russo, Daniel Mailo, Yun-Fu Hu, Gabriela Balogh, Fathima Sheriff, and Irma H. Russo

Dual Role of Transforming Growth Factor ß in Mammary Tumorigenesis and Metastatic Progression
Rebecca S. Muraoka-Cook, Nancy Dumont, and Carlos L. Arteaga

Insulin-like Growth Factor-I and Breast Cancer Therapy
Yasir H. Ibrahim and Douglas Yee

Short-term Changes in KI-67 During Neoadjuvant Treatment of Primary Breast Cancer with Anastrozole or Tamoxifen Alone or Combined Correlate with Recurrence-Free Survival
Mitch Dowsett, Ian E. Smith, Steve R. Ebbs, J. Michael Dixon, Anthony Skene, Clive Griffith, Irene Boeddinghaus, Janine Salter, Simone Detre, Margaret Hills, Susan Ashley, Stephen Francis, Geraldine Walsh, on behalf of the IMPACT trialists