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Innovations and Challenges in Renal Cancer

Second Cambridge Conference
April 2006

Table of Contents

Innovations and Challenges in Melanoma: Summary Statement from the Second Cambridge Conference
MB Atkins, MS Ernstoff, RA Figlin, KT Flaherty, DJ George, WG Kaelin, Jr, ED Kwon, TA Libermann, WM Linehan, DF McDermott, AC Ochoa, AJ Pantuck, BI Rini, MA Rosen, JA Sosman, VP Sukhatme, JW Vieweg, CG Wood, L King

Identification of the Genes for Kidney Cancer: Opportunity for Disease-Specific Targeted Therapeutics
WM Linehan, PA Pinto, R Srinivasan, M Merino, P Choyke, L Choyke, J Coleman, J Toro, G Glenn, C Vocke, B Zbar, LS Schmidt, D Bottaro, and L Neckers

The von Hippel-Lindau Tumor Suppressor Protein and Clear Cell Renal Carcinoma
W G Kaelin, Jr,

Genomics of Renal Cell Cancer: The Biology Behind and the Therapy Ahead
J Jones, and TA Libermann

Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma: Is It Still Imperative in the Era of Targeted Therapy?
A J Pantuck, AS Belldegrun, and RA Figlin

Multimodal Approaches in the Management of Locally Advanced and Metastatic Renal Cell Carcinoma:  Combining Surgery and Systemic Therapies to Improve Patient Outcome
CG Wood

Protein Expression Profiles in Renal Cell Carcinoma: Staging, Prognosis, and Patient Selection for Clinical Trials
JS Lam, AJ Pantuck, AS Belldegrun, and RA Figlin

Implications of B7-H1 Expression in Clear Cell Carcinoma of the Kidney for Prognostication and Therapy
RH Thompson, H Dong and ED Kwon

Update on the Application of Interleukin-2 in the Treatment of Renal Cell Carcinoma
DF McDermott

Arginase, Prostaglandins, and Myeloid Suppressor Cells in Renal Cell Carcinoma
AC Ochoa,  A Zea, C Hernandez, and PC Rodriguez

Reversal of Tumor-Mediated Immunosuppression
J Vieweg, Z Su, P Dahm, and S Kusmartsev

Developing a Rational Tumor Vaccine Therapy for Renal Cell Carcinoma: Immune Yin and Yang
MS Ernstoff, TS Crocenzi, JD Seigne, NA Crosby, BF Cole, JL Fisher, JC Uhlenhake, D Mellinger, C Foster, CJ Farnham, K Mackay, ZM Szczepiorkowski, SM Webber, AR Schned, RD Harris, RJ Noelle, RJ Barth, Jr, JA Heaney

Biologic Aspects and Binding Strategies of Vascular Endothelial Growth Factor in Renal Cell Carcinoma
BI Rini and WK Rathmell

Sorafenib in Renal Cell Carcinoma
KT Flaherty

Phase 2 Studies of Sunitinib and AG013736 in Patients With Cytokine-refractory Renal Cell Carcinoma
DJ George

The Role of mTOR Inhibitors in the Treatment of Advanced Renal Cancer
D Cho, S Signoretti, M Regan, JW Mier, MB Atkins

Opportunities and Obstacles to Combination Targeted Therapy in Renal Cell Cancer
JA Sosman, I Puzanov, and MB Atkins

Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Assessing Tumor Vascularity and Vascular Effects of Targeted Therapies in Renal Cell Carcinoma
MA Rosen and MD Schnall

Controversies in Angiogenic Monitoring
RS Bhatt, P Seth, and VP Sukhatme