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Endocrine and Targeted Manipulation of Breast Cancer

Sixth Cambridge Conference
May 2007

Table of Contents

Endocrine Manipulation of Breast Cancer:  Summary Statement from the 6th Cambridge Conference
Steven E. Come, Aman U. Buzdar , James N. Ingle, Stephen RD Johnston, Angela M. Brodie, Charles Coombes, William R. Miller, Kathleen I. Pritchard, Eric P. Winer, Jo Anne Zujewski, Paul E. Goss

Preclinical Modeling of Endocrine Response and Resistance: Focus on Aromatase Inhibitors
Luciana F. Macedo, Gauri Sabnis, Angela Brodie

Predicting Response and Resistance to Endocrine Therapy:  Profiling Patients on Aromatase Inhibitors
William R Miller, Alexey Larionov, Thomas J Anderson, John R Walker, Andreas Krause, Dean B Evans, and J Michael Dixon

Pharmacogenomics of tamoxifen and aromatase inhibitors
James N. Ingle

Summary of Aromatase Inhibitor Clinical Trials in Postmenopausal Women with Early Breast Cancer
Aman U. Buzdar, Charles Coombes, Paul E. Goss, Eric P. Winer

Enhancing Endocrine Response with Novel Targeted Therapies – Why Have the Clinical Trials to date Failed to Deliver on the Pre-clinical Promise?
Stephen RD Johnston

Combining Endocrine Agents with Chemotherapy: Which Patients and What Sequence?
Kathleen I. Pritchard

Current NCI-sponsored Cooperative Group Trials of Endocrine Therapies in Breast Cancer
Jennifer Eng-Wong, Jo Anne Zujewski